Published January 15, 2005
by New York Academy of Sciences .
Written in English
|Contributions||H. Leon Bradlow (Editor), Luigi Castagnetta (Editor), Luisa Massimo (Editor), Kurt Zaenker (Editor)|
|The Physical Object|
|Number of Pages||499|
Cell signaling is a field that studies how cells communicate to control basic activities and respond to their environment. When looking specifically at cancer cells, researchers can gain a better understanding of cancer on a cellular level, an understanding that may . Signal transduction and communication in cancer cells. New York, N.Y.: New York Academy of Sciences, (DLC) Material Type: Conference publication, Document, Internet resource: Document Type: Internet Resource, Computer File: All Authors / Contributors: H Leon Bradlow; New York Academy of Sciences. Click on the title to browse this issue. The Cellular Communication in Cancer Program explores the molecular signals within and between cells that drive cancer. Researchers in this Program are developing innovative new models for human tumors and advanced imaging technology with a goal of identifying potential “druggable” targets and mechanisms of drug resistance in cancer.
Abstract. There are many different signaling pathways that contribute to development and cellular homeostasis. In diseases, especially cancer, development components of these pathways often become mutated or overexpressed causing dysregulation of cellular signaling. This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Suppression of these exaggerated signals may be one way to reduce cell proliferation in cancer. Purpose of Signal Transduction. Signal amplification • increasing a signal so that minimal receptor occupation by small amounts of neurotransmitters in the synapse produces significant cellular responses. The Importance of Good Communication: Cell Signaling and How it Relates to Cancer. In , the United States Congress declared May as Cancer Research Month. We know that supporting cancer research is important, ultimately leading to earlier detection, better treatments, possibly even a cure.
Cancer is a complex disease caused by genetic and/or epigenetic changes in one cell or a group of cells. These alterations disrupt ‘normal’ cell function and cause cancerous cells to over proliferate and avoid mechanisms that would typically control their growth, division, and migration. 1,2 Many of these ‘disruptions’ map to specific cell signaling pathways. A signal is detected when the chemical signal (also known as a ligand) binds to a receptor protein on the surface of the cell or inside the cell. 2. Transduction: When the signaling molecule binds the receptor it changes the receptor protein in some way. This change initiates the process of transduction. Signal transduction is usually a pathway. Home > Research > Signal Transduction. Signal Transduction "The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Introduction. Cell signal transduction refers to the binding of extracellular factors to a receptor (membrane receptor or nuclear receptor), triggering a series of biochemical reactions and protein interactions in the cell, until the genes which required for cellular physiological reactions begin to express and the process of forming biological effects.